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KMID : 0387720140250030260
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Korean Journal of Blood Transfusion
2014 Volume.25 No. 3 p.260 ~ p.273
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Factors Predicting Peripheral Blood Stem Cell Collection: Analysis of Korean Patients at a Single Center
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장민중:Jang Min-Joong
조덕:Cho Duck/신명근:Shin Myung-Geun/양동욱:Ryang Dong-Wook
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Abstract
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malignancies and some solid cancers. Effective mobilization and collection of PBSC is essential for successful PBSC transplantation. The aim of this study was to investigate the useful factors for predicting PBSC collection using multivariate analysis.
Methods: We retrospectively reviewed the medical records of 170 allogeneic and 389 autologous donors at Chonnam National University Hwasun Hospital between 2005 and 2012. Donor groups were divided into three groups (failure group, suboptimal group, and optimal group) according to the total CD34+ yield. Donors were compared regarding age, sex, body weight, disease, complete blood count, hematopoietic progenitor cell (HPC) parameter of automated cell counter, process volume, number of leukapheresis procedures, prior mobilization history, type of vascular access and instrument.
Results: In allogeneic PBSC collections (n=170), the collection failure group showed lower baseline (premobilization) white blood cell (WBC) (P=0.004) and HPC (P＜0.001) than the optimal group. In autologous PBSC collections (n=389), the collection failure group showed lower baseline HPC and more frequent prior mobilization history (P＜0.001) than the suboptimal and optimal group. In multivariate analysis, older age, lower number of leukapheresis procedures, and prior mobilization history were risk factors associated with mobilization failure.
Conclusion: Our data suggest that baseline WBC and HPC would be useful for predicting poor mobilizer in allogeneic PBSC collection, whereas baseline HPC would be useful in autologous PBSC collection. Conventional chemotherapy and G-CSF based remobilization would not be helpful to proven poor mobilizer in previous mobilization. (Korean J Blood Transfus 2014;25:260-273)
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KEYWORD
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Hematopoietic stem cell mobilization, Transplantation, Risk factors
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